Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Identifieur interne : 001956 ( Main/Exploration ); précédent : 001955; suivant : 001957Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Auteurs : V. Stalin Raj ; Huihui Mou ; Saskia L. Smits [Pays-Bas] ; Dick H. W. Dekkers ; Marcel A. Müller ; Ronald Dijkman ; Doreen Muth ; Jeroen A. A. Demmers ; Ali Zaki [Arabie saoudite] ; Ron A. M. Fouchier ; Volker Thiel ; Christian Drosten ; Peter J. M. Rottier ; Albert D. M. E. Osterhaus ; Berend Jan Bosch ; Bart L. HaagmansSource :
- Nature [ 0028-0836 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Bronchioles (cytologie), Cellules COS, Cellules épithéliales (virologie), Chiroptera, Coronavirus (), Coronavirus (métabolisme), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Données de séquences moléculaires, Humains, Infections à coronavirus (génétique), Infections à coronavirus (métabolisme), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Récepteurs viraux (génétique), Récepteurs viraux (métabolisme), Spécificité d'hôte.
- MESH :
- cytologie : Bronchioles.
- génétique : Dipeptidyl peptidase 4, Infections à coronavirus, Récepteurs viraux.
- métabolisme : Coronavirus, Dipeptidyl peptidase 4, Infections à coronavirus, Récepteurs viraux.
- virologie : Cellules épithéliales, Infections à coronavirus.
- épidémiologie : Infections à coronavirus.
- Animaux, Cellules COS, Chiroptera, Coronavirus, Données de séquences moléculaires, Humains, Spécificité d'hôte.
English descriptors
- KwdEn :
- Animals, Bronchioles (cytology), COS Cells, Chiroptera, Chlorocebus aethiops, Coronavirus (classification), Coronavirus (metabolism), Coronavirus Infections (epidemiology), Coronavirus Infections (genetics), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Epithelial Cells (virology), Host Specificity, Humans, Molecular Sequence Data, Receptors, Virus (genetics), Receptors, Virus (metabolism).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4, Receptors, Virus.
- classification : Coronavirus.
- cytology : Bronchioles.
- epidemiology : Coronavirus Infections.
- genetics : Coronavirus Infections.
- metabolism : Coronavirus, Coronavirus Infections, Dipeptidyl Peptidase 4, Receptors, Virus.
- virology : Coronavirus Infections, Epithelial Cells.
- Animals, COS Cells, Chiroptera, Chlorocebus aethiops, Host Specificity, Humans, Molecular Sequence Data.
Abstract
Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the receptor that this virus uses to infect cells.
The online version of this article (doi:10.1038/nature12005) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nature12005
PubMed: 23486063
PubMed Central: 7095326
Affiliations:
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Le document en format XML
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Osterhaus</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.5645.2</institution-id><institution-id institution-id-type="ISNI">000000040459992X</institution-id><institution>Department of Viroscience,</institution><institution>Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands,</institution></institution-wrap>,</nlm:aff></affiliation></author><author><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend Jan" last="Bosch">Berend Jan Bosch</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.5477.1</institution-id><institution-id institution-id-type="ISNI">0000000120346234</institution-id><institution>Virology Division, Department of Infectious Diseases & Immunology,</institution><institution>Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, the Netherlands,</institution></institution-wrap>,</nlm:aff></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.5645.2</institution-id><institution-id institution-id-type="ISNI">000000040459992X</institution-id><institution>Department of Viroscience,</institution><institution>Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands,</institution></institution-wrap>,</nlm:aff></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bronchioles (cytology)</term><term>COS Cells</term><term>Chiroptera</term><term>Chlorocebus aethiops</term><term>Coronavirus (classification)</term><term>Coronavirus (metabolism)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (genetics)</term><term>Coronavirus Infections (metabolism)</term><term>Coronavirus Infections (virology)</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Epithelial Cells (virology)</term><term>Host Specificity</term><term>Humans</term><term>Molecular Sequence Data</term><term>Receptors, Virus (genetics)</term><term>Receptors, Virus (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Bronchioles (cytologie)</term><term>Cellules COS</term><term>Cellules épithéliales (virologie)</term><term>Chiroptera</term><term>Coronavirus ()</term><term>Coronavirus (métabolisme)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Infections à coronavirus (génétique)</term><term>Infections à coronavirus (métabolisme)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Récepteurs viraux (génétique)</term><term>Récepteurs viraux (métabolisme)</term><term>Spécificité d'hôte</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Bronchioles</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bronchioles</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dipeptidyl peptidase 4</term><term>Infections à coronavirus</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Coronavirus</term><term>Coronavirus Infections</term><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Coronavirus</term><term>Dipeptidyl peptidase 4</term><term>Infections à coronavirus</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>COS Cells</term><term>Chiroptera</term><term>Chlorocebus aethiops</term><term>Host Specificity</term><term>Humans</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules COS</term><term>Chiroptera</term><term>Coronavirus</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Spécificité d'hôte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the receptor that this virus uses to infect cells.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nature12005) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Drexler, Jf" uniqKey="Drexler J">JF Drexler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Rk" uniqKey="Williams R">RK Williams</name></author><author><name sortKey="Jiang, Gs" uniqKey="Jiang G">GS Jiang</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yeager, Cl" uniqKey="Yeager C">CL Yeager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delmas, B" uniqKey="Delmas B">B Delmas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schultze, B" uniqKey="Schultze B">B Schultze</name></author><author><name sortKey="Herrler, G" uniqKey="Herrler G">G Herrler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lambeir, Am" uniqKey="Lambeir A">AM Lambeir</name></author><author><name sortKey="Durinx, C" uniqKey="Durinx C">C Durinx</name></author><author><name sortKey="Scharpe, S" uniqKey="Scharpe S">S Scharpe</name></author><author><name sortKey="De Meester, I" uniqKey="De Meester I">I De Meester</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boonacker, E" uniqKey="Boonacker E">E Boonacker</name></author><author><name sortKey="Van Noorden, Cj" uniqKey="Van Noorden C">CJ Van Noorden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Burkett, Se" uniqKey="Burkett S">SE Burkett</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author><author><name sortKey="Pickles, Rj" uniqKey="Pickles R">RJ Pickles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huynh, J" uniqKey="Huynh J">J Huynh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K Wu</name></author><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Wilken, M" uniqKey="Wilken M">M Wilken</name></author><author><name sortKey="Geraghty, Rj" uniqKey="Geraghty R">RJ Geraghty</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Berg, Dl" uniqKey="Van Den Berg D">DL van den Berg</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend Jan" last="Bosch">Berend Jan Bosch</name><name sortKey="Dekkers, Dick H W" sort="Dekkers, Dick H W" uniqKey="Dekkers D" first="Dick H. W." last="Dekkers">Dick H. W. Dekkers</name><name sortKey="Demmers, Jeroen A A" sort="Demmers, Jeroen A A" uniqKey="Demmers J" first="Jeroen A. A." last="Demmers">Jeroen A. A. Demmers</name><name sortKey="Dijkman, Ronald" sort="Dijkman, Ronald" uniqKey="Dijkman R" first="Ronald" last="Dijkman">Ronald Dijkman</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><name sortKey="Mou, Huihui" sort="Mou, Huihui" uniqKey="Mou H" first="Huihui" last="Mou">Huihui Mou</name><name sortKey="Muller, Marcel A" sort="Muller, Marcel A" uniqKey="Muller M" first="Marcel A." last="Müller">Marcel A. Müller</name><name sortKey="Muth, Doreen" sort="Muth, Doreen" uniqKey="Muth D" first="Doreen" last="Muth">Doreen Muth</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name><name sortKey="Rottier, Peter J M" sort="Rottier, Peter J M" uniqKey="Rottier P" first="Peter J. M." last="Rottier">Peter J. M. Rottier</name><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Zaki, Ali" sort="Zaki, Ali" uniqKey="Zaki A" first="Ali" last="Zaki">Ali Zaki</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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